Studies on 1H-imidazo[12-b]pyrazole Derivatives

A development of Groebke-Blackburn-Bienaymé (GBB) reaction was shown by the application of Etidronic acid as a green catalyst. The title compounds were prepared via multicomponent GBB reaction in one pot sequential steps by the condensation of 2-amino-1H-pyrazol aldehyde and isonitrile. Here we have demonstrated the development of GBB protocol by the utility of Etidronic acid in milder reaction medium to modify and simplify the existing synthetic strategies that removes hazardous acids toxic solvents and drastic conditions with sustainable product yields and purity.