Studies on the Synthesis & Characterization of Mangiferin Analogues

The naturally occurring xanthone glycoside mangiferin has been isolated by column chromatography from the ethanolic extract of stem bark of Mangifera indica. Mangiferin was further converted to Mangiferin-octa-Acetate Mangiferin-tetra-benzoate 5-(N-phenylamino methyleno) mangiferin 5-(N-p-chlorophenylamino methyleno) mangiferin 5-(N-2-methyl phenylamino methyleno) mangiferin 5-(N-p-Methoxy phenylamino methyleno) mangiferin 5-(N N-Diphenylamino methyleno) mangiferin 5-(N--Napthylamino methyleno)-mangiferin 5-(N-4-methyl phenylamino methyleno) mangiferin 5-(N-m-Nitrophenylamino methyleno) mangiferin 5-(N-p-flurophenylamino methyleno) mangiferin Octa-o-methyl mangiferin Mangiferin-9- Oxime. Mangiferin and its analogues were characterized by mp Rf UV IR and NMR spectral analyses. These compounds were screened for antimicrobial activity. Among the compound tested only MPAMM-4 a mangiferin derivative was found to be more effective than other compounds against both bacteria (Escherichia coli) and fungus (Aspergillus niger).