Synthesis and Biological Evaluation of Some New Imidazoles

This work has been carried out to investigate the following: The first project represents the reactions of ethylidenethiosemicarbazone with DMAD or substituted methylenemalononitriles gave thiazolidin-4-one or 13-thiazine derivatives respectively. Also treatment of ethylidenethiosemicarbazide with hydrazonoyl halides α-haloketones and chloroacetic acid afforded the corresponding arylazothiazoles thiazoles and thiazolidenone derivative respectively. The anti-cancer activity of the selected products against the colon carcinoma cell line (HCT-116) was determined and the results revealed promising activity.The second project involves the synthesis of a novel series of pyridine and bipyridine derivatives is described via one-pot multi-component reaction of 5-acetylimidazole malononitrile (or ethyl cyanoacetate or diethyl malonate) substituted benzaldehyde (or terephthaldehyde) and ammonium acetate in good yields. The antimicrobial activities of the synthesized compounds were screened and the results showed that most of them exhibit considerable activities. Also some of the newly synthesized compounds were screened for their anticancer activity against two cell lines.