Synthesis and characterization of a pyrazole derivative-��-CD complex

Amino pyrazole belongs to anti-inflammatory class and is characterized by a low solubility in water. (In order to increase its solubility in water inclusion complex of amino pyrazole with ?-CD was obtained.)The inclusion complex obtained between AMP and ?-cyclodextrin was characterized by FT-IR 1H NMR 1H–1H NOESY 13C NMR DEPT XHCOR spectra through TG analysis DTA DSC and Scanning Electron Microscopy (SEM). The stoichiometry of inclusion complex is 1:1 (guest–host) and K stability is 1.1 ×104 M-1.