Synthesis and characterization of Triazolo[43-c]pyrimidine library

A novel [124]triazolo[43-c]pyrimidine-8-carboxamide libraries were synthesized via oxidative cyclization of hydrazono-16-dihydropyrimidine-5-carboxamide intermediates by the application of Iodobenzenediacetate as a sole cyclizating agent. Here we report one pot sequential strategy to generate corresponding triazolopyrimidines by condensation of preprepared α-acylketene dithioacetals and arylamidines. Moreover this process describes the application of presynthesized arylamidines which omits the transition metal catalyzed Suzuki-Miyaura cross coupling reaction hence signify the atom- and step-economic methodology.