Synthesis Of Novel Anti-inflammatory Agents With Good Gastric Profiles

Inflammation is a worldwide distributing disease annoying a lot of people so it is necessary to discover drugs that are capable of eliminating this disease. This dissertation concerned with synthesis of novel indole derivatives as indomethacin analogues. As we Know indomethacin is one of the most potent anti-inflammatory agents but with high gastric toxicity due to its non selective inhibition of both COX isozymes. So we decided to synthesize these compounds which characterized by high potency and great safety gastric profiles.