Synthesis of Some Dihydropyrimidinones and Pharmacological Activity

This research revealed that the numbers of available heterocyclic compounds are mainly focused on nitrogen-containing compounds such as quinazolines indoles benzimidazole quinoxalines coumarins and pyrimidines etc. A mixture of substituted aldehydes (0.01 mol) like acetylacetone (method 1) or ethyl acetoacetate (method 2) urea or thiourea (0.01 mol) and lemon juice (0.5 ml) were taken into a round bottom flask and reflux for 1 hour under continuous stirring. After completion of the reaction the final product was recrystallized for purification. Simultaneously toxicity and anti-inflammatory activity were performed. But in case of using ethyl acetoacetate in method 2 the percentage yield was more as compared to using acetylacetone in method 1. So the derivatives obtained from method 2 were selected for further toxicity and anti-inflammatory activities.