Synthesis of Some Novel Bioactive Indoles as Anticancer Agents

The original work consists of two projects: In the first project: 5-(Aryldiazenyl)-thiazoles and 134-thiadiazoles bearing indole were synthesized via reaction of hydrazonoyl halides and indole-thiosemicarbazone and alkyl (indolyl)carbodithioate respectively. In the second project: 3-Acetylindole proved to be a useful precursor for the synthesis of various 13-thiazoles 134-thiadiazoles and pyrido[32-e][124] triazolo[43-a]pyrimidin-5(7H)-one. Fifteen of the new compounds have been evaluated for their antitumor activity against the human breast carcinoma cell line. The results indicated that many of the tested compounds showed moderate to high anticancer activity.