Synthesis of Sulfonamide by Metal Catalyzed Sulfonamidation

A sulfonamide is the basis of several sulfa drugs. So a lot of work has gone into creating new sulfonamides using metal-free synthesis which either uses sulfinate salts as intermediates or reacts amino compounds with sulfonyl chlorides. Unfortunately the processes used to synthesize sulfonyl chlorides—such as oxidative chlorination of organ sulfur and electrophilic aromatic substitution with chlorosulfonic acid—often suffer from severe reaction conditions a narrow range of applicability. So this book discusses numerous effective techniques such as transition-metals-catalyzed synthesis developed for the synthesis of sulfonamide.