Synthetic Methodologies ~ Biologically Relevant Privileged Scaffold

Privileged structures are molecular scaffolds with versatile binding properties such that a single scaffold is able to provide potent and selective ligands for a range of different biological targets through the simple manipulation of the functional groups. In addition privileged structures typically exhibit good drug-like properties which in turn leads to more drug-like compound libraries and leads. In this book the possibility to develop a versatile methodology for the syntheis of biologically relevant privileged scaffolds is deeply explored. The first part of the book is focused on the development of a multicomponent approach for the synthesis of Dihydropirans and Sugars. The second part of the book is focused on the synthesis and the biological evaluation against HIV virus of derivatives with a rhodaninc structure. Finally the third part regards the attemps to synthesize the indenic privileged structure as a strategy to obtain the natural product Cyanosporoside.