Taxol

This volume brings together all aspects of TAXOL® research, development, and clinical use. It provides comprehensive knowledge of the compound and a perspective of the complex interrelationships needed for its development and production. Each chapter is written by an authority in the field. Chapters are carefully coordinated to maximize information on key topics while avoiding overlap and duplication. Previously unpublished material is presented along with thorough reviews of each topic. <p>Introduction<br>Discovery and Development of TAXOL®, M. Suffness and M.E. Wall<br>Yew and Us: A Brief History of the Yew Tree. H.R. Hartzell, Jr.<br>Supply of TAXOL®<br>Taxus for TAXOL® and Taxoids, E.M. Croom, Jr.<br>Potential of Plant Cell Culture for Taxane Production, D.M. Gibson, R.E.B. Ketchum, T.J. Hirasuna, and M.L. Shuler<br>Semisynthesis of TAXOL® and Taxotere, R.A. Holton, R.J. Biediger, and P. Douglas Boatman<br>Toward the Total Synthesis of TAXOL® and Its Analogues, P.A. Wender, M.G. Natchus, and A.J. Shuker<br>Biology of TAXOL®<br>Biosynthesis of TAXOL®, H.G. Floss and U. Mocek<br>Preclinical Antitumor Activity of Taxanes, W.C. Rose<br>Biopharmaceutics of Paclitaxel (TAXOL®): Formulation, Activity, and Pharmacokinetics, R.M. Straubinger<br>The Use of TAXOL® in Cell Biology, R.B. Vallee<br>Chemistry of TAXOL®<br>Detection and Isolation, K.M. Snader<br>Natural Taxoids: Structure and Chemistry, D.G.I. Kingston<br>The Medicinal Chemistry of TAXOL® , G.I. Georg, T.C. Boge, Z.S. Cheruvallath, J.S. Clowers, G.C.B. Harriman, M. Hepperie, and H. Park<br>Clinical Studies<br>TAXOL® : Clinical Results and Current Issues in Development, S.G. Arbuck and B.A. Blaylock<br>Index</p>