Temporal Targeting of P2X4 Receptors in Stroke

This book explores the emerging therapeutic potential of purinergic signaling modulation across different stages of cerebrovascular injury. It presents a comprehensive overview of how P2X4 receptor activation or inhibition affects microglial polarization neuroinflammation neuronal survival and post-stroke behavioral outcomes. Integrating molecular neuroscience pharmacology and translational medicine the text delineates the dual temporal roles of P2X4 receptors-early neuroprotection in acute ischemia and regulation of neuroplasticity to mitigate chronic post-stroke depression. The book highlights recent experimental models receptor-selective ligands and clinical perspectives for designing time-sensitive interventions that bridge acute neuroprotection with long-term mental health recovery in stroke patients.