Textbook of Ion Channels Volume II

<p>The <i>Textbook of Ion Channels </i>is a set of three volumes that provides a wide-ranging refer- ence source on ion channels for students instructors and researchers. Ion channels are membrane proteins that control the electrical properties of neurons and cardiac cells; mediate the detection and response to sensory stimuli like light sound odor and taste; and regulate the response to physical stimuli like temperature and pressure. In non-excit- able tissues ion channels are instrumental for the regulation of basic salt balance that is critical for homeostasis. Ion channels are located at the surface membrane of cells giving them the unique ability to communicate with the environment as well as the membrane of intracellular organelles allowing them to regulate internal homeostasis. Ion channels are fundamentally important for human health and diseases and are important targets for pharmaceuticals in mental illness heart disease anesthesia pain and other clinical appli- cations. The modern methods used in their study are powerful and diverse ranging from single ion-channel measurement techniques to models of ion channel diseases in animals and human clinical trials for ion channel drugs.</p><p>Volume II starts with ion channel taxonomy and features coverage of major ion channel families and describes the physiological role structural components gating mechanisms and biophysics permeation and selectivity regulation pharmacology and roles in dis- ease mechanisms. Channels in this volume include voltage-activated sodium calcium and potassium channels inward-rectifier and two-pore domain potassium channels calcium- activated potassium channels cyclic nucleotide-gated channels pacemaker ion channels chloride channels ligand-gated receptors activated by acetylcholine glutamate 5-HT3 GABA and glycine acid-sensing channels P2X receptors TRP channels store-operated channels pressure-activated piezo channels ryanodine receptors and proton channels.</p><p>All three volumes give the reader an introduction to fundamental concepts needed to understand the mechanism of ion channels; a guide to the technical aspects of ion channel research; offer a modern guide to the properties of major ion channel families; and include coverage of key examples of regulatory physiological and disease roles for ion channels.</p>