The Bidirectional Association between Diabetes and Alzheimer���s Disease

About 60–70% of diabetics exhibit mild to severe forms of nervous system damage. Understanding the link between type 2 diabetes mellitus and Alzheimer’s disease is increasingly important. This study was a trial to focus light on several aspects associated with type 2 diabetes that contribute to Alzheimer’s disease and vice versa. In addition the present study revealed the importance of Aβ40 Aβ42 insulin HbA1c lipid profile disturbance CRP D-dimer and magnesium in the bidirectional association between type 2 diabetes and Alzheimer’s disease pathogenesis which is powered by their association and thus the possibility of depending on the amyloid beta as biochemical marker of type 2 diabetes in Alzheimer's patients was suggested. Also in future new therapeutic potentials such as neutralization of Aβ by anti-Aβ antibodies could be a new strategy for addressing insulin resistance and diabetes.