The Effect of Calorie Restriction and Intermittent Fasting on Health and Disease

Recent biochemical studies indicate that calorie restriction (CR) is a widely accepted method for anti-aging intervention. CR and intermittent fasting (IF) which involves reduced calories but proper nutritional intake during specific periods are interventions that can consistently promote health benefits delay biological aging and extend both average and maximal lifespan. Furthermore CR can modulate age-related diseases such as Alzheimers disease atherosclerosis diabetes obesity cancer and others. Advances in omics technologies have provided a technical breakthrough that enabled the investigation of DNA RNA proteins and other cellular molecules and their comprehensive interactions in a biological context. Nowadays it is possible to analyze and integrate biological processes that occur in aging systems at the molecular level using state-of-the-art techniques such as next-generation sequencing (NGS) proteomics lipidomics metabolomics and epigenomics. Omics technology and systems gerontology provide predictive information on CR effects molecular mechanisms and pathways underlying the anti-aging actions of CR and IF. This Special Issue The effects of calorie restriction and intermittent fasting on health and disease focuses on the effects of calorie restriction and intermittent fasting on age-related inflammation autophagy metabolism longevity mitochondrial function and age-related diseases.