Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality in developed countries. What is less appreciated perhaps is that the great majority of CVD is associated with alterations to the arterial system. The effect of aging on CVD is illustrated simply but powerfully by the observation that the risk of CVD increases progressively with age. Given the current and projected increases in the number of older adults in North America we face the possibility of a ‘new wave’ of CVD in the near future and an associated increase in healthcare burden. Determining how arteries change with respect to age and increased risk of CVD the mechanisms by which these alterations are mediated integrated with strategies for the prevention and treatment of arterial aging are therefore among our highest biomedical priorities.
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