The host's immune response against dengue virus infections

One of the biggest global public health issues is dengue virus (DENV) infection particularly in tropical areas of the world where 75% of dengue cases occur. While most DENV infections are moderate or asymptomatic about 5% of cases go on to develop a severe version of the illness. This is primarily related to several infections with various DENV serotypes that occurred in succession. Numerous immunopathogenic pathways involving virus and host variables influence the severity of dengue. New research suggests that an inadequate immune response by limiting viral clearance and causing severe inflammation which ultimately results in dengue hemorrhagic fever and dengue shock syndrome contributes to the progression and severity of the disease. The natural history of viral infections notably dengue is greatly influenced by the host''s innate and adaptive immune responses. In this context it has been noted that RNA interference (RNAi) is becoming more prevalent in viral infection processes and immune defense in recent years.