Todayneurological disordersneuromuscular disorders is very important in creating. Including neurological disordersincluding Migraine disease.Migraine disease is a neuromuscular disorder that commonly causes A progressive neurodegenerative disease with autosomal dominant inheritancewith the incidence in adulthoodthe disease has three abnormal movementscognitive disorders psychological disorders known.Migraine disease is caused by genetic mutationsbut also epigenetic factors are critical in inducing the disease.In this study we have analyzed 200 people.100 Migraine disease and 100 control group.The gene NOTCH3 analyzed in terms of genetic mutation made.In this studypeople who have genetic mutation were targetedwith nervous disordersMigraine disease.In fact of all people with Migraine disease.100 Migraine disease had a genetic mutation in the gene NOTCH3 Migraine disease.Any genetic mutations in the target genes control groupdid not show.