The Role of Polymorphism of Interleukin 10 and 12 in Hepatitis C

Chronic infection with hepatitis C virus (HCV) is a huge problem both globally and at the level of the individual patient. The natural outcome and response to treatment in hepatitis C virus (HCV) infection varies between individuals. It was aimed to detect single nucleotide polymorphisms (SNPs) of the IL-I0 promoter region at nucleotides -1082 &-592 and IL-12 promotor region at nucleotide -1188. also we measured Il-10 and IL12 protein level in the serum of chronic liver diseased patients under treatment with peg IFN- plus ribavirin and compare the results with non infected subjects.