The Shaping of Cancer by the Tumour Microenvironment and Its Relevance for Cancer Therapy

In this book we present a compilation of original research articles as well as review articles that are focused on improving our understanding of the molecular and cellular mechanisms by which cancer cells adapt to their microenvironment. These include the interplay between cancer cells and the surrounding microenvironmental cells (e.g. macrophages tumor-infiltrating lymphocytes and myeloid cells) and microenvironmental environments (e.g. oxidative stress pH hypoxia) and the implications of this dynamic interaction to tumor radioresistance chemoresistance invasion and metastasis. Finally the importance and relevance of these findings are translated to cancer therapy.