Natural products have a wide range of diversity of multidimensional chemical structures which play a vital role which show the important nature as golden source for achieving the herbal drug discovery. Natural products have played a key role in drug discovery and development in modern days. Thymoquinone has a wide a range of beneficial pharmacological properties including antioxidant anticancer anti-inflammatory hypoglycemic neuro- cardio- nephro- and hepatoprotective with tremendous immune-modulating property.