This study introduce quick reliable and reproducible prognostic and diagnostic tool for Colorectal and Breast cancer patients coupling serum TGF-β1 level to quantitative gene expression in blood samples. Serum TGF-β1 level previously reported significance as a diagnostic prognostic and even therapeutic decisive tool is confirmed showing significant correlation to solid tumor type and size. Blood TGF-β1 quantitative gene expression is offered as an easy quick and reproducible tool ensuring serum TGF-β1 level reliability.