Transmethylations and the Central Nervous System

V M. ANDREOLl A. AGNOLI and C. FAZIO The transfer of a methyl group from a donor to an acceptor compound is a fundamental biochemie al process long since known to biologists; the process is involved for instance in the metabolism of porphyrins nuc1eic acids and fatty acids. Only recently however did transmethylation processes reveal their decisive role in CNS biochemistry - namely with the discovery that such processes are linked with the biogenie amines that have been conc1usively identified as the chemical mediators of neu- ronal transmission and more broadly of behavior. The first suggestion that transmethylation processes might be involved in the origina- tion of certain mental diseases came from Harley-Mason (1952) who noticed that many of the hallucinogenic substances known at that time contained methyl radicals and par- ticularly that mescaline represented the product of O-methylation of dopamine in posi- tions 3 4 and 5. This hypothesis was put forward when the O-methylation of catechol- amines by catechol-O-methyltransferases had not yet been described. Harley-Mason further proposed that in the living organism the process of O-methyla- tion might follow a \deviant\ metabolie pathway and that the accumulation of abnor- mal methylated metabolites endowed with hallucinogenic properties might be responsi- ble for the implementation of some mental diseases notably schizophrenia. He also called attention to a substance 34-dimethoxyphenylethylamine (34-DMPEA) as a possible psychotogenic moleeule on the strength of its capacity for producing cata- tonia in experimental animals.