Understanding Amyotrophic Lateral Sclerosis: Causes and Management

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder marked by muscle weakness atrophy fasciculations and spasticity due to motor neuron degeneration. Symptoms progress from focal weakness to difficulties in speaking swallowing and breathing with eventual paralysis. The disease arises from mechanisms such as disrupted RNA metabolism (e.g. TDP-43 and FUS mutations) cytoskeletal and axonal transport defects (e.g. PFN1 TUBA4A mutations) excitotoxicity and oxidative stress. While incurable treatments like Riluzole and Edaravone can modestly slow progression and supportive care-such as non-invasive ventilation feeding tubes and physical therapy-helps manage symptoms. Emerging therapies including gene and RNA-targeted approaches hold promise for the future.