Validation & Stability Indicating RP-HPLC Method for Meloxicam Capsule

Meloxicam (4-hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-12-benzothiazine-3carboxamide-11 -dioxide) is an NSAID used in the management of rheumatic disease which is distinguished by the fact that it is well tolerated by the stomach at the doses necessary for therapy. The anti-inflammatory and pain-relieving properties of Meloxicam make this active substance very interesting for use in pain therapy. Meloxicam act as nonselective inhibitor of the enzyme cyclooxygenase (COX) inhibiting both the cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) isoenzymes. A rapid specific isocratic RP-HPLC method has been developed for the determination of Meloxicam capsules using a UV/diode array detector. The method was validated as per ICH guidelines and USP/NF. Therefore this method can be useful for routine analysis of Meloxicam capsules as bulk drug and dosage form.