VITAMIN D AND ITS EFFECTS IN CRANIOFACIAL GROWTH

Vitamin D plays a pivotal role in Craniofacial growth by regulating calcium-phosphorus balance bone mineralization and gene expression via the vitamin D receptor (VDR) in bone cartilage and dental tissues. Chronic deficiency defined by 25(OH)D levels below 20-30 ng/mL can impair jaw development leading to underdeveloped maxilla or mandible crowding narrow arches high palates and increased risk of crossbites. Thus ensuring adequate vitamin D levels during growth through sun exposure diet or supplementation is essential not only for systemic bone health but also for optimal craniofacial and dental development. This Dissertation contains the metabolism of Vitamin D in detail with particular emphasis of its effect in growth and development of the Craniofacial skeleton.