Wheat germ oil derived from the germ of Triticum aestivum is among the richest natural sources of vitamin E essential fatty acids phytosterols carotenoids and bioactive peptides. Its unique composition imparts potent antioxidant anti-inflammatory cardioprotective hepatoprotective nephroprotective neuroprotective and anti-aging effects positioning it as a promising nutraceutical and therapeutic agent. Clinical and experimental research demonstrates WGO's capacity to reduce oxidative stress alter lipid metabolism control inflammatory signaling pathways and maintain tissue integrity in diseases like diabetes hypercholesterolemia osteoporosis nephrotoxicity hepatotoxicity and postmenopausal complications. Despite these benefits WGO's shelf life and bioefficacy are limited by its high polyunsaturated fatty acid content which makes it extremely vulnerable to oxidation. Recent developments in micro- and nanoencapsulation technologies have improved its stability bioavailability and suitability for use in pharmaceuticals cosmeceuticals functional foods and nutraceuticals by employing buttermilk proteins phospholipids and polysaccharides.
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