Mitochondrial Signaling in Health and Disease

<p>Mitochondria have traditionally been associated with metabolic functions; however recent research has uncovered a central role for these organelles in cell signaling cell survival and cell death. Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions including age-related neurodegenerative disorders cancer metabolic syndrome and cardiovascular disease. <strong>Mitochondrial Signaling in Health and Disease </strong>examines themes essential for the maintenance of the mitochondrial redox (reduction-oxidation) energy axis.</p><p>With contributions from an impressive cadre of internationally recognized scientists the book discusses coordinated mitochondrial functions that regulate cell function by discrete signaling pathways. Topics discussed include: </p><ul> <p> </p> <li>Electron transport and energy production</li> <li>Mitochondrial biogenesis and dynamics</li> <li>Mitochondrial signaling</li> <li>Apoptosis and autophagy</li> <li>Pharmacology signaling</li> <li>Epigenetic signaling: mitochondrial methylation and acetylation reactions</li> </ul><p>An essential resource for life and health scientists as well as pharmaceutical industry professionals this volume highlights the importance of mitochondrial signaling and its role in establishing a harmonized communication between several cellular compartments. The information in this volume is critical to those developing mitochondrion-targeted therapies aimed at assuaging mitochondrial dysfunction or the specific factors contributing to its dysfunction.</p>