Mark Twain, considered one of the greatest writers in American literature, was born Samuel Clemens in Florida, Missouri, in 1835, and died in Redding, Connecticut in 1910. As a young child, he moved with his family to Hannibal, Missouri, on the banks of the Mississippi River, a setting that inspired his two best-known novels, The Adventures of Tom Sawyer and Adventures of Huckleberry Finn.